Could Lymphocyte Caspase-3 Activity Predict Atherosclerotic Plaque Vulnerability?
نویسندگان
چکیده
منابع مشابه
Lymphocyte migration into atherosclerotic plaque.
Adaptive immunity is involved in the pathogenesis of atherosclerosis, but the recruitment of T and B lymphocytes to atherosclerotic lesions is not as well studied as that of monocytes. In this review, we summarize the current understanding of the role of lymphocyte subsets in the pathogenesis of atherosclerosis and discuss chemokines and chemokine receptors involved in lymphocyte homing to athe...
متن کاملSmall entities with large impact: microcalcifications and atherosclerotic plaque vulnerability
PURPOSE OF REVIEW Atherosclerotic plaque rupture and subsequent acute events, such as myocardial infarction and stroke, contribute to the majority of cardiovascular-related deaths. Calcification has emerged as a significant predictor of cardiovascular morbidity and mortality, challenging previously held notions that calcifications stabilize atherosclerotic plaques. In this review, we address th...
متن کاملTissue characterization of atherosclerotic plaque vulnerability by nuclear magnetic resonance.
Developing imaging technologies capable of identifying unstable atheromatous plaques in vivo is a major issue of clinical cardiovascular research. These techniques would permit an earlier surgical or medical therapy and would anticipate acute ischemic syndromes. Plaque vulnerability depends on the relative amount and thickness of its lipid core and fibrous cap. Several means of assessing athero...
متن کاملRelationship of MMP-14 and TIMP-3 Expression with Macrophage Activation and Human Atherosclerotic Plaque Vulnerability
Matrix metalloproteinase-14 (MMP-14) promotes vulnerable plaque morphology in mice, whereas tissue inhibitor of metalloproteinases-3 (TIMP-3) overexpression is protective. MMP-14(hi) TIMP-3(lo) rabbit foam cells are more invasive and more prone to apoptosis than MMP-14(lo) TIMP-3(hi) cells. We investigated the implications of these findings for human atherosclerosis. In vitro generated macropha...
متن کاملPlaque neovascularization is increased in ruptured atherosclerotic lesions of human aorta: implications for plaque vulnerability.
BACKGROUND Growth of atherosclerotic plaques is accompanied by neovascularization from vasa vasorum microvessels extending through the tunica media into the base of the plaque and by lumen-derived microvessels through the fibrous cap. Microvessels are associated with plaque hemorrhage and may play a role in plaque rupture. Accordingly, we tested this hypothesis by investigating whether microves...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Journal of Medical Biochemistry
سال: 2010
ISSN: 1452-8266,1452-8258
DOI: 10.2478/v10011-010-0010-2